Acute Exercise Stimulates Carnitine Biosynthesis and OCTN2 Expression in Mouse Kidney

@article{Broderick2017AcuteES,
  title={Acute Exercise Stimulates Carnitine Biosynthesis and OCTN2 Expression in Mouse Kidney},
  author={Tom L Broderick and Frank A Cusimano and Chelsea Carlson and Leslie K. Tamura},
  journal={Kidney and Blood Pressure Research},
  year={2017},
  volume={42},
  pages={398 - 405}
}
Background/Aims: Carnitine is essential for the transport of long-chain FAs (FA) into the mitochondria for energy production. During acute exercise, the increased demand for FAs results in a state of free carnitine deficiency in plasma. The role of kidney in carnitine homeostasis after exercise is not known. Methods: Swiss Webster mice were sacrificed immediately after a 1-hour moderate intensity treadmill run, and at 4-hours and 8-hours into recovery. Non-exercising mice served as controls… Expand
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