Acute Effects of Vitamin C on Platelet Responsiveness to Nitric Oxide Donors and Endothelial Function in Patients with Chronic Heart Failure

@article{Ellis2001AcuteEO,
  title={Acute Effects of Vitamin C on Platelet Responsiveness to Nitric Oxide Donors and Endothelial Function in Patients with Chronic Heart Failure},
  author={G. Ellis and R. Anderson and Y. Chirkov and J. Morris-Thurgood and S. Jackson and M. Lewis and J. Horowitz and M. Frenneaux},
  journal={Journal of Cardiovascular Pharmacology},
  year={2001},
  volume={37},
  pages={564-570}
}
Chronic heart failure (CHF) is characterized by a prothrombotic state, which may relate to increased platelet aggregability, endothelial dysfunction, and increased oxidative stress. We investigated the effect of vitamin C in CHF on ex vivo platelet aggregation and platelet responsiveness to the anti-aggregatory effects of the nitric oxide (NO) donors glyceryl trinitrate (GTN) and sodium nitroprusside (SNP). We also examined parameters of oxidative stress and endothelial function in patients. In… Expand

Paper Mentions

Interventional Clinical Trial
This study is to test a low-cost, simple vitamin C supplementation intervention, that is, comparing placebo to 500 mg/day vitamin C and 1 gram/day vitamin C daily to assess… Expand
ConditionsHeart Failure
InterventionDietary Supplement, Other
Hydralazine does not Ameliorate Nitric Oxide Resistance in Chronic Heart Failure
New tricks for an old drug.
Oxidative stress and endothelial dysfunction: Therapeutic implications
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References

SHOWING 1-10 OF 30 REFERENCES
Oral vitamin C reduces arterial stiffness and platelet aggregation in humans.
Nitrate resistance in platelets from patients with stable angina pectoris.
Platelet function, thrombin and fibrinolytic activity in patients with heart failure.
Increased oxidative stress in patients with congestive heart failure.
N-Acetylcysteine potentiates nitroglycerin-induced reversal of platelet aggregation.
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