Acute Effects of Oral Pirbuterol on Myocardial Oxygen Metabolism and Systemic Hemodynamics in Chronic Congestive Heart Failure

@article{Rude1981AcuteEO,
  title={Acute Effects of Oral Pirbuterol on Myocardial Oxygen Metabolism and Systemic Hemodynamics in Chronic Congestive Heart Failure},
  author={Robert E. Rude and Zoltan G Turi and Edward J. Jr. Brown and Beverly H. Lorell and Wilson S. Colucci and Gilbert H. Mudge and C R Taylor and William Grossman},
  journal={Circulation},
  year={1981},
  volume={64},
  pages={139–145}
}
Pirbuterol hydrochloride, an orally effective, B-adrenergic agonist, improves hemodynamic abnormalities in patients with congestive heart failure, but its effects on myocardial oxygen consumption (MVO2) and coronary blood flow have not been characterized. We studied the effects of 20-30 mg of oral pirbuterol on myocardial metabolic and hemodynamic parameters in 12 patients (six with coronary artery disease) with chronic CHF refractory to standard medical therapy. Pirbuterol induced an increase… 
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