Acute Effects of Cocaine on Human Brain Activity and Emotion

@article{Breiter1997AcuteEO,
  title={Acute Effects of Cocaine on Human Brain Activity and Emotion},
  author={Hans C. Breiter and Randy L. Gollub and Robert M. Weisskoff and David N. Kennedy and Nikos Makris and Joshua D. Berke and Julie M. Goodman and Howard L Kantor and David R. Gastfriend and Jonn P Riorden and R Mathew and Bruce R. Rosen and Steven E Hyman},
  journal={Neuron},
  year={1997},
  volume={19},
  pages={591-611}
}

• Hans C. Breiter, Randy L. Gollub, +10 authors Steven E Hyman
• Published 1997 in Neuron
• DOI:10.1016/S0896-6273(00)80374-8

We investigated brain circuitry mediating cocaine-induced euphoria and craving using functional MRI (fMRI). During double-blind cocaine (0.6 mg/kg) and saline infusions in cocaine-dependent subjects, the entire brain was imaged for 5 min before and 13 min after infusion while subjects rated scales for rush, high, low, and craving. Cocaine induced focal signal increases in nucleus accumbens/subcallosal cortex (NAc/SCC), caudate, putamen, basal forebrain, thalamus, insula, hippocampus… CONTINUE READING

Save to Library

Create Alert

Cite

View on Elsevier