Acute Effects of Cocaine on Human Brain Activity and Emotion

  title={Acute Effects of Cocaine on Human Brain Activity and Emotion},
  author={Hans C. Breiter and Randy L. Gollub and Robert M. Weisskoff and David N. Kennedy and Nikos Makris and Joshua D. Berke and Julie M. Goodman and Howard L Kantor and David R. Gastfriend and Jonn P Riorden and R Mathew and Bruce R. Rosen and Steven E Hyman},
We investigated brain circuitry mediating cocaine-induced euphoria and craving using functional MRI (fMRI). During double-blind cocaine (0.6 mg/kg) and saline infusions in cocaine-dependent subjects, the entire brain was imaged for 5 min before and 13 min after infusion while subjects rated scales for rush, high, low, and craving. Cocaine induced focal signal increases in nucleus accumbens/subcallosal cortex (NAc/SCC), caudate, putamen, basal forebrain, thalamus, insula, hippocampus… CONTINUE READING
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