Acute Dose Response of Intraocular Pressure to Topical and Oral Cannabinoids

@article{Green1977AcuteDR,
  title={Acute Dose Response of Intraocular Pressure to Topical and Oral Cannabinoids},
  author={K. Green and K. Kim},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1977},
  volume={154},
  pages={228 - 231}
}
  • K. Green, K. Kim
  • Published 1977
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
Summary Three nitrogen-containing can-nabinoids caused a dose-dependent fall of intraocular pressure when administered either topically or orally to rabbits. Concentrations of 0.001 to 1% applied topically and 0.3 mg/kg orally were effective. Topical concentrations of 0.5% caused a substantial decrease of intraocular pressure in rhesus monkeys. These compounds may prove therapeutically useful in the treatment of elevated intraocular pressure. This work was supported in part by PHS Research… Expand
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