Acute D-serine treatment produces antidepressant-like effects in rodents.

  title={Acute D-serine treatment produces antidepressant-like effects in rodents.},
  author={Oz Malkesman and Daniel R. Austin and Tyson R Tragon and Gang Wang and Gregory R. Rompala and Anahita B. Hamidi and Zhenzhong Cui and W Scott Young and Kazu Nakazawa and Carlos A. Zarate and Husseini K. Manji and Guang Chen},
  journal={The international journal of neuropsychopharmacology},
  volume={15 8},
Research suggests that dysfunctional glutamatergic signalling may contribute to depression, a debilitating mood disorder affecting millions of individuals worldwide. Ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist, exerts rapid antidepressant effects in approximately 70% of patients. Glutamate evokes the release of D-serine from astrocytes and neurons, which then acts as a co-agonist and binds at the glycine site on the NR1 subunit of NMDA receptors. Several studies have implicated… CONTINUE READING
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