Acute Alcoholic Hepatitis.

  title={Acute Alcoholic Hepatitis.},
  author={Gene Y. Im},
  journal={Clinics in liver disease},
  volume={23 1},
  • G. Im
  • Published 1 February 2019
  • Medicine
  • Clinics in liver disease

Acute exacerbated severe form of nonalcoholic steatohepatitis leading to acute-on-chronic liver failure: A case series

Three patients with uncontrolled metabolic syndrome and acute-on-chronic liver failure are presented in whom the acute event was found to be a severe and exacerbated form of nonalcoholic steatohepatitis (NASH), a novel entry in the natural history of non-alcoholic fatty liver disease.

Outcomes of Hospitalized Acute Alcoholic Hepatitis (AH) in Patients With Bipolar 1 Disorder (B1D)

This study indicates that B1D may be an independent protective factor against acute hepatic failure in patients hospitalized with AH, and can be explained by frequent laboratory monitoring and psychiatric assessments performed by psychiatrists treating B 1D patients, as well as the impact B1d has on cortisol release induced by hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis.

Utility of platelet indices in alcoholic hepatitis: a retrospective study

platelet indices appear to be significantly altered in alcoholic hepatitis, but they do not predict severe disease.

LncRNA 1700020I14Rik promotes AKR1B10 expression and activates Erk pathway to induce hepatocyte damage in alcoholic hepatitis

In vitro cell experiments and in vivo animal experiments validated that 1700020I14Rik reduced ethanol-induced hepatocyte damage and inflammation in AH mice through regulation of miR-137–mediated AKR1B10/Erk axis.

Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis

Data indicate that chronic stress and corticosterone exacerbate alcohol-induced mucosal barrier dysfunction, endotoxemia, and systemic alcohol responses, and Corticosterone-mediated promotion ofcohol-induced intestinal epithelial barrier dysfunction and modulation of gut microbiota may play a crucial role in the mechanism of stress-induced promotion of alcohol-associated tissue injury at the GLB axis.



Alcoholic hepatitis: current challenges and future directions.

  • A. SingalP. KamathG. GoresV. Shah
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2014

Is liver biopsy necessary in the management of alcoholic hepatitis?

There remains a definite role for liver biopsy where there is clinical diagnostic doubt or dual pathology and it adds value in a clinical trial context to ensure a homogeneous trial population and to further the understanding of the disease pathology.

Management of alcoholic hepatitis.

Recurrent Alcoholic Cirrhosis In Severe Alcoholic Relapse After Liver Transplantation: A Frequent and Serious Complication

Recurrent alcoholic cirrhosis after LT occurs in <6% of ALD transplant patients, and one-third of severe alcoholic relapse patients develop RAC <5 years after transplantation with a very poor prognosis.

Original Articles: Liver Failure and Liver DiseaseEarly change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone

ECBL is a very simple predictive factor for identifying nonresponders to corticosteroids and a recommendation to discontinue cortICosteroids after 7 days in patients without ECBL, suggested by the results, awaits additional confirmation.

Acute-on-chronic liver failure: a new clinical entity.

  • R. MoreauV. Arroyo
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2015

Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy

The combination of an elevated leukocyte count and a nodular liver surface in the absence of active infection retrospectively identified patients with a high likelihood of histologic AH for whom liver biopsy may not be necessary.

Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study

Patients with ACLF have a high short-term mortality but those who survived the acute exacerbation show a long-term outcome comparable to that of patients with CHD, and early signs of infection, positive systemic inflammatory response syndrome criteria at admission and ductular bilirubinostasis predicted outcome in ACLF.