Acute, subchronic and discontinuation effects of zopiclone on sleep EEG and nocturnal melatonin secretion

@article{Mann1996AcuteSA,
  title={Acute, subchronic and discontinuation effects of zopiclone on sleep EEG and nocturnal melatonin secretion},
  author={Klaus Mann and H. Bauer and Christoph Hiemke and Joachim R{\"o}schke and Hermann Wetzel and Otto Benkert},
  journal={European Neuropsychopharmacology},
  year={1996},
  volume={6},
  pages={163-168}
}
Zopiclone is a new short half-life cyclopyrrolone hypnotic agent acting at the GABA-benzodiazepine receptor complex. In order to characterize its pharmacological profile, the effects of 7.5 mg zopiclone on nocturnal melatonin secretion were investigated under polysomnographic control in 11 healthy subjects following acute and subchronic administration as well as after abrupt discontinuation of the drug. No effect of zopiclone on the melatonin plasma levels could be observed. Regarding both… Expand
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