Acute, subacute, and chronic histologic effects of simulated aspiration of a 0.7% sucralfate suspension in rats.

@article{Shepherd1995AcuteSA,
  title={Acute, subacute, and chronic histologic effects of simulated aspiration of a 0.7% sucralfate suspension in rats.},
  author={Kieran M. Shepherd and Chessa D Faulkner and Gary Thal and James C Leiter},
  journal={Critical care medicine},
  year={1995},
  volume={23 3},
  pages={
          532-6
        }
}
OBJECTIVE To assess the acute (4-hr), subacute (7-day), and chronic (21-day) effects of simulated aspiration of a 0.7% sucralfate suspension in rats. DESIGN Prospective, multigroup trial in which rats were randomized to various simulated aspiration groups. SETTING Experimental animal laboratory. SUBJECTS Forty-five Sprague-Dawley rats. INTERVENTIONS Simulated aspiration was induced by single, direct, tracheal instillation of 2 mL/kg of either room air, sucralfate, or normal saline… CONTINUE READING
BETA