Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents.

Abstract

Diaveridine (DVD) is a member of the 2,4-pyrimidinediamine class of dihydrofolate reductase inhibitors. It is used in combination with sulfaquinoxaline as an antiprotozoal agent in animals for the prophylaxis and treatment of coccidiosis and leucocytozoonosis. Herein, we report a complete toxicological safety assessment of DVD for clinical use. The study of… (More)
DOI: 10.1016/j.etap.2015.08.022

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