Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal clonidine in the rodent formalin test and in a neuropathic pain model.

@article{Yoon2009AcupointSW,
  title={Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal clonidine in the rodent formalin test and in a neuropathic pain model.},
  author={S Y Yoon and D H Roh and Young-Bae Kwon and Hyun-Woo Kim and H Seo and Ho-jae Han and Hye-jung Lee and Alvin James Beitz and Jang-Hern Lee},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2009},
  volume={10 3},
  pages={253-63}
}
UNLABELLED Although intrathecal (i.t.) administration of the alpha(2)-adrenoceptor agonist clonidine has a pronounced analgesic effect, the clinical use of clonidine is limited by its side effects. Previously, our laboratory has demonstrated that the subcutaneous injection of diluted bee venom (DBV) into an acupoint (termed apipuncture) produces significant analgesic effect in various pain animal models. The present study was designed to examine whether DBV injection into the Zusanli acupoint… CONTINUE READING