Acuminolide A: structure and bioactivity of a new polyether macrolide from dinoflagellate Dinophysis acuminata.

@article{Hwang2014AcuminolideAS,
  title={Acuminolide A: structure and bioactivity of a new polyether macrolide from dinoflagellate Dinophysis acuminata.},
  author={Buyng Su Hwang and Heong Seop Kim and Wonho Yih and Eun Ju Jeong and Jung-Rae Rho},
  journal={Organic letters},
  year={2014},
  volume={16 20},
  pages={
          5362-5
        }
}
Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 was characterized by detailed analysis of 2D NMR and MS data. Its relative stereochemistry was elucidated on the basis of ROESY correlations and J-based analysis. In contrast to the other well-known toxins that were isolated, 1 showed no cytotoxicity… Expand
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