Aculeatin, a coumarin derived from Toddalia asiatica (L.) Lam., enhances differentiation and lipolysis of 3T3-L1 adipocytes.

@article{Watanabe2014AculeatinAC,
  title={Aculeatin, a coumarin derived from Toddalia asiatica (L.) Lam., enhances differentiation and lipolysis of 3T3-L1 adipocytes.},
  author={Akiharu Watanabe and Tsuyoshi Kat{\^o} and Yusuke Ito and Izumi Yoshida and Teppei Harada and Takashi Mishima and Kazuhiro Fujita and Masatoshi Watai and Kiyotaka Nakagawa and Taiki Miyazawa},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={453 4},
  pages={
          787-92
        }
}
Toddalia asiatica (L.) Lam. (T. asiatica) has been utilized traditionally for medicinal purposes such as the treatment of diabetes. Currently, the extract is considered to be a good source of anti-diabetic agents, but the active compounds have yet to be identified. In this study, we investigated the effects of fractionated T. asiatica extracts on the differentiation of 3T3-L1 preadipocytes and identified aculeatin as a potential active agent. When 3T3-L1 preadipocytes were treated with… CONTINUE READING
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