Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.

  title={Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.},
  author={David P Lalonde and Michael C. Brown and Brian P Bouverat and C. Heath Turner},
  journal={The Journal of biological chemistry},
  volume={280 22},
The focal adhesion protein actopaxin contributes to integrin-actin associations and is involved in cell adhesion, spreading, and motility. Herein, we identify and characterize an association between actopaxin and the serine/threonine kinase testicular protein kinase 1 (TESK1), a ubiquitously expressed protein previously reported to regulate cellular spreading and focal adhesion formation via phosphorylation of cofilin. The interaction between actopaxin and TESK1 is direct and the binding sites… CONTINUE READING
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