Actomyosin contraction at the cell rear drives nuclear translocation in migrating cortical interneurons.

@article{Martini2010ActomyosinCA,
  title={Actomyosin contraction at the cell rear drives nuclear translocation in migrating cortical interneurons.},
  author={Francisco J. Martini and Miguel Valdeolmillos},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 25},
  pages={8660-70}
}
Neuronal migration is a complex process requiring the coordinated interaction of cytoskeletal components and regulated by calcium signaling among other factors. Migratory neurons are polarized cells in which the largest intracellular organelle, the nucleus, has to move repeatedly. Current views support a central role for pulling forces that drive nuclear movement. The participation of actomyosin driven forces acting at the nucleus rear has been suggested, however its precise contribution has… CONTINUE READING

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Calcium signaling

  • DP Darcy, JS Isaacson
  • 2009
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