Actomyosin contractility rotates the cell nucleus

@inproceedings{Kumar2014ActomyosinCR,
  title={Actomyosin contractility rotates the cell nucleus},
  author={Abhishek Kumar and Ananyo Maitra and Madhuresh Sumit and S. N. Ramaswamy and G. V. Shivashankar},
  booktitle={Scientific reports},
  year={2014}
}
The cell nucleus functions amidst active cytoskeletal filaments, but its response to their contractile stresses is largely unexplored. We study the dynamics of the nuclei of single fibroblasts, with cell migration suppressed by plating onto micro-fabricated patterns. We find the nucleus undergoes noisy but coherent rotational motion. We account for this observation through a hydrodynamic approach, treating the nucleus as a highly viscous inclusion residing in a less viscous fluid of orientable… CONTINUE READING
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