Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy

  title={Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy},
  author={Brian J. Bacskai and Peter Wall{\'e}n and Varda Lev-Ram and Sten Grillner and Roger Tsien},
In lamprey spinal cord, intracellular calcium ([Ca2+]i) plays a key role in mechanisms regulating neuronal activity in the segmental network for locomotion. In this report, measurements of [Ca2+]i with fluo-3 in various regions of motoneurons in the intact spinal cord were obtained on a high speed confocal microscope following electrical stimulation. Likewise, rhythmic calcium fluctuations within dendrites and axons were seen during "fictive swimming" and were directly correlated with… CONTINUE READING


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