Activity regulates the levels of acetylcholine receptor a-subunit mRNA in cultured chicken myotubes ( allelic variants / restriction fragment-length polymorphism / control of mRNA accumulation / denervation hypersensitivity )


In vitro blocking the spontaneous activity of primary cultures of chicken embryo myotubes with tetrodotoxin increases ~2-fold their content in surface acetylcholine receptor. To investigate this effect at the level of gene expression, chicken genomic DNA sequences coding for the acetylcholine receptor a subunit were isolated and characterized. They were… (More)

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