Activity-regulated phosphorylation of cAMP response element binding protein in the developing striatum: implications for patterning the neurochemical phenotypes of striatal compartments.

@article{Liu1998ActivityregulatedPO,
  title={Activity-regulated phosphorylation of cAMP response element binding protein in the developing striatum: implications for patterning the neurochemical phenotypes of striatal compartments.},
  author={F C Liu and Ann M. Graybiel},
  journal={Developmental neuroscience},
  year={1998},
  volume={20 2-3},
  pages={229-36}
}
A distinct feature of the striatum is that much of the expression of neurochemicals in this forebrain structure follows a compartmental (striosome/matrix) ordering. How this pattern of neurochemical compartmentation is developed and regulated is still unknown. In the present paper we propose that a key feature of this early striatal plasticity is differential control of the activation kinetics of the cAMP response element binding protein (CREB), which in turn influences striatal expression of… CONTINUE READING