Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells

@article{Kraus2007ActivityPO,
  title={Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells},
  author={Marianne Kraus and Thomas R{\"u}ckrich and Michael P Reich and Jeannette Gogel and AndrewH. Beck and Winfried Kammer and Celia R Berkers and Danny Burg and Herman S Overkleeft and Huib Ovaa and Christoph Driessen},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={84-92}
}
Proteasomal proteolysis relies on the activity of six catalytically active proteasomal subunits (β1, β2, β5, β1i, β2i and β5i). Applying a functional proteomics approach, we used a recently developed activity-based, cell-permeable proteasome-specific probe that for the first time allows differential visualization of individual active proteasomal subunits in intact primary cells. In primary leukemia samples, we observed remarkable variability in the amounts of active β1/1i-, β2/2i- and β5/5i… CONTINUE READING
38 Extracted Citations
23 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 38 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 23 references

Similar Papers

Loading similar papers…