Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas

  title={Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas},
  author={Audrey Laroche and Vanessa Chaire and François Le Loarer and Marie-Paule Alg{\'e}o and Christophe Rey and Kevin Tran and Carlo Lucchesi and Antoine Italiano},
  booktitle={Journal of hematology & oncology},
BACKGROUND Trabectedin has recently been approved in the USA and in Europe for advanced soft-tissue sarcoma patients who have been treated with anthracycline-based chemotherapy without success. The mechanism of action of trabectedin depends on the status of both the nucleotide excision repair (NER) and homologous recombination (HR) DNA repair pathways. Trabectedin results in DNA double-strand breaks. We hypothesized that PARP-1 inhibition is able to perpetuate trabectedin-induced DNA damage… CONTINUE READING
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