Activity of the plasma membrane H(+)-ATPase and optimal glycolytic flux are required for rapid adaptation and growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid.

@article{Holyoak1996ActivityOT,
  title={Activity of the plasma membrane H(+)-ATPase and optimal glycolytic flux are required for rapid adaptation and growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid.},
  author={Caroline D. Holyoak and Malcolm Stratford and Z. MCMULLIN and Martin B Cole and K A Crimmins and Allyson J Brown and Peter J Coote},
  journal={Applied and environmental microbiology},
  year={1996},
  volume={62 9},
  pages={3158-64}
}
The weak acid sorbic acid transiently inhibited the growth of Saccharomyces cerevisiae in media at low pH. During a lag period, the length of which depended on the severity of this weak-acid stress, yeast cells appeared to adapt to this stress, eventually recovering and growing normally. This adaptation to weak-acid stress was not due to metabolism and removal of the sorbic acid. A pma1-205 mutant, with about half the normal membrane H+-ATPase activity, was shown to be more sensitive to sorbic… CONTINUE READING