Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma.

@article{Zhu2015ActivityOT,
  title={Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma.},
  author={Yun-rong Zhu and Han Min and Jian-Feng Fang and Feng Zhou and Xiong-Wei Deng and Yun-Qing Zhang},
  journal={Cancer biology & therapy},
  year={2015},
  volume={16 4},
  pages={602-9}
}
Recent studies have identified that constitutively active phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is an important feature of osteosarcoma, where it promotes cell proliferation, survival, and chemo-resistance. Here, we studied the therapeutic potential of NVP-BEZ235, a novel dual PI3K/mTOR dual inhibitor, on… CONTINUE READING