Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

@article{Liu2002ActivityOT,
  title={Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.},
  author={Mingfu Liu and S. Douthwaite},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 6},
  pages={
          1629-33
        }
}
Methylation of specific nucleotides in rRNA is one of the means by which bacteria achieve resistance to macrolides-lincosamides-streptogramin B (MLS(B)) and ketolide antibiotics. The degree of resistance is determined by how effectively the rRNA is methylated. We have implemented a bacterial system in which the rRNA methylations are defined, and in this study we investigate what effect Erm mono- and dimethylation of the rRNA has on the activity of representative MLS(B) and ketolide antibiotics… CONTINUE READING

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