Activity of the alternative pathway of complement in the newborn infant.

@article{Adamkin1978ActivityOT,
  title={Activity of the alternative pathway of complement in the newborn infant.},
  author={David H. Adamkin and A E Stitzel and Joan R. Urmson and Mary Lou Farnett and Ernest M. Post and Roger E. Spitzer},
  journal={The Journal of pediatrics},
  year={1978},
  volume={93 4},
  pages={
          604-8
        }
}
Levels of C3, properdin, factor B, and C3 to C9 activity were markedly reduced in cord sera taken from 94 normal newborn infants. Nevertheless, cord serum supported complete activation of its own alternative pathway by zymosan or CoF. Lysis of a target cell, however, was defective; nearly 75% of cord sera had reduced rabbit erythrocyte CH50 titers. These were partially increased by the addition of factor B and properdin, and totally restored by adding factor B, properdin, and C3 to C9… CONTINUE READING

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