Activity of the Na,K-ATPase α4 isoform is regulated during sperm capacitation to support sperm motility.

@article{Jimenez2012ActivityOT,
  title={Activity of the Na,K-ATPase α4 isoform is regulated during sperm capacitation to support sperm motility.},
  author={Tamara Tatiana Jimenez and G. Mart{\'i}nez Sanchez and Gustavo Blanco},
  journal={Journal of andrology},
  year={2012},
  volume={33 5},
  pages={
          1047-57
        }
}
The α4 polypeptide is a testis-specific isoform of the catalytic subunit of the Na,K-ATPase, which is essential for sperm motility and fertility. In the present study, we have investigated the regulation of activity of the α4 isoform and the relevance of this event for sperm capacitation. We have performed this by taking advantage of the selective high affinity of α4 for the inhibitor ouabain. Our results show that ouabain-sensitive hydrolysis of ATP and uptake of (86)Rb, corresponding to the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Similar Papers

Loading similar papers…