Activity of the Na+/H+ exchanger contributes to cardiac damage following ischaemia and reperfusion.

Abstract

1. The present review considers the evidence that Na+-H+ exchange activity contributes to cardiac damage following ischaemia and reperfusion. The basic mechanism involved is that protons are produced during ischaemia and leave the myocytes on the Na+/H+ exchanger during either ischaemia and/or reperfusion. The resulting elevation of [Na+]i causes Ca2… (More)

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