Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America

@article{Ressner2008ActivityOT,
  title={Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America},
  author={Roseanne A. Ressner and Matthew R. Moore and James H. Jorgensen},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2008},
  volume={52},
  pages={1147 - 1149}
}
ABSTRACT Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active, with a MIC50 of 0.25 μg/ml, a MIC90 of 0.5 μg/ml, and a range of ≤0.008 μg/ml to 1 μg/ml. 
2 Citations

Antistreptococcal Activity of AR-709 Compared to That of Other Agents

ABSTRACT Against 300 strains of pneumococci and 100 group A streptococci of differing β-lactam, macrolide, and quinolone resistance phenotypes, AR-709 was very active, with all MICs being ≤2 μg/ml.

A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung

The results of this microdose study indicate that AR-709 attains concentrations appreciably higher within the lung than in plasma, its low oral bioavailability however, precludes oral administration.

References

SHOWING 1-10 OF 21 REFERENCES

Hidden Epidemic of Macrolide-resistant Pneumococci

An overview of macrolide-resistant S. pneumoniae is provided and the impact of this resistance on the empiric treatment of community-acquired RTIs is assessed.

Antimicrobial resistance among Streptococcus pneumoniae in the United States: have we begun to turn the corner on resistance to certain antimicrobial classes?

  • G. DoernS. Richter S. Beekmann
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
It appears that, as fluoroquinolone resistance emerges among S. pneumoniae in the United States, resistance to other antimicrobial classes is becoming less common and rates of resistance to beta -lactams, macrolides, tetracyclines, TMP-SMX, and multiple drugs have either plateaued or have begun to decrease.

Management of Infections Due to Antibiotic-Resistant Streptococcus pneumoniae

Antibiotic-resistant strains of Streptococcus pneumoniae are becoming more prevalent throughout the world; this has resulted in modifications of treatment approaches and recommendations for treating other systemic infections are evolving.

A review of clinical failures associated with macrolide-resistant Streptococcus pneumoniae.

Predicting antimicrobial resistance in invasive pneumococcal infections.

Knowledge of antimicrobial use during the 3 months before infection is crucial for determining appropriate therapy for a patient presenting to the hospital with an illness for which S. pneumoniae is a possible cause.

Diversity and antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae carriage isolates in the post-heptavalent conjugate vaccine era.

The decreased prevalence of antibiotic resistance with the introduction of heptavalent pneumococcal conjugate vaccine is likely to be partially eroded over time as vaccine-included serotypes are replaced by resistant clones of NVTs.

Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae.

The rate of antibiotic-resistant invasive pneumococcal infections decreased in young children and older persons after the introduction of the conjugate vaccine, and there was an increase in infections caused by serotypes not included in the vaccine.

Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically : approved standard

This document describes standard broth dilution and microdilution and agar dilution techniques and includes a series of procedures to standardize the way the tests are performed, and the performance, applications, and limitations of the current CLSI-recommended methods are described.

Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically : Approved standard

This document describes standard broth dilution and microdilution and agar dilution techniques and it includes a series of procedures to standardize the way the tests are performed, and the performance, applications, and limitations of the current CLSI-recommended methods are described.

Increased Antimicrobial Resistance Among Nonvaccine Serotypes of Streptococcus pneumoniae in the Pediatric Population After the Introduction of 7-Valent Pneumococcal Vaccine in the United States

The proportion of S. pneumoniae isolates from U.S. pediatric patients covered by PCV7 decreased substantially in the 4 years after vaccine introduction, however, resistance to commonly used antimicrobials, including β-lactams and macrolides, as well as multidrug-resistant strains increased significantly among respiratory tract isolates of NVS.