Activity of spiramycin against chlamydia, in vitro and in vivo.

In-vitro and in-vivo studies were performed to assess the activity of spiramycin against chlamydiae. In tissue culture spiramycin exhibited very good activity against Chlamydia trachomatis but less against C. psittaci. C. psittaci was also studied in a mouse experimental model. There was 100% clinical cure of the mice with 50 mg/kg, demonstrating excellent… (More)