Activity of receptor guanylyl cyclases in rats with neonatal streptozotocin diabetes and effect of intranasal administration of insulin and serotonin

@article{Shpakov2011ActivityOR,
  title={Activity of receptor guanylyl cyclases in rats with neonatal streptozotocin diabetes and effect of intranasal administration of insulin and serotonin},
  author={Alexander Shpakov and Oksana V. Chistyakova and Kira Derkach and Irina V. Moyseyuk and Vera M. Bondareva},
  journal={Cell and Tissue Biology},
  year={2011},
  volume={5},
  pages={453-462}
}
In diabetes mellitus (DM) and its complications the functional activity of hormonal signaling systems and their sensitivity to the regulatory action of hormones are changed. We studied the activity of receptor forms of guanylyl cyclase (rGC) sensitive to natriuretic peptides ANP and CNP in the tissues of female rats with 240 day neonatal streptozotocin DM and the effects of intranasal administration of insulin and serotonin (6 weeks, daily dose for rat is 0.48 IU insulin or 20 μg serotonin). In… CONTINUE READING

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