Activity of pyruvate kinase and lactic acid dehydrogenase in mouse lung after transplacental exposure to carcinogenic and non-carcinogenic chemicals.

Abstract

The carcinogenic urethane (URTH), dimethylnitrosamine (DMN), 3-methylcholanthrene (MCA), benzo[a]pyrene (BP), 7,12-dimethylbenz[a]anthracene (DMBA) and aflatoxin B1 (B1) administered to pregnant CFLP mice increased the activity of pyruvate kinase (PK) and lactate dehydrogenase (LDH) and decreased the ratio of LDH H and M subunits in the lungs of offsprings… (More)

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