Activity of physalins purified from Physalis angulata in in vitro and in vivo models of cutaneous leishmaniasis.

@article{Guimares2009ActivityOP,
  title={Activity of physalins purified from Physalis angulata in in vitro and in vivo models of cutaneous leishmaniasis.},
  author={Elisalva Teixeira Guimar{\~a}es and Milena da Silva Lima and Luana Almeida dos Santos and I Maria Miguel Ribeiro and Therezinha Coelho Barbosa Tomassini and Ricardo Ribeiro dos Santos and Washington Lu{\'i}s Conrado Dos Santos and Milena Botelho Pereira Soares},
  journal={The Journal of antimicrobial chemotherapy},
  year={2009},
  volume={64 1},
  pages={
          84-7
        }
}
OBJECTIVES We have previously demonstrated the immunomodulatory effects of physalins, secosteroids purified from Physalis angulata. Here we investigate the antileishmanial activity of physalins in vitro and in vivo in a model of cutaneous leishmaniasis. METHODS The antileishmanial activity of physalins B, D and F was tested in Leishmania-infected macrophage cultures. For the in vivo studies, BALB/c mice were infected with Leishmania amazonensis subcutaneously in the ear pinna and treated with… CONTINUE READING

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