Activity of phenothiazines against medically important yeasts.

  title={Activity of phenothiazines against medically important yeasts.},
  author={Yael Eilam and Itzhack Polacheck and G Ben-Gigi and Dov Chernichovsky},
  journal={Antimicrobial agents and chemotherapy},
  volume={31 5},
Two phenothiazine compounds, trifluoperazine and chlorpromazine, inhibited growth in vitro of the five most common pathogenic yeasts, with MICs ranging from 10 to 40 micrograms/ml. Daily intraperitoneal injections of trifluoperazine (4 to 7 mg/kg of body weight) increased the survival of mice experimentally infected with Candida albicans or Cryptococcus neoformans. The potential use of these drugs against fungal meningitis is discussed. 

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