Activity of pentosan polysulphate and derived compounds on vascular endothelial cell proliferation and migration induced by acidic and basic FGF in vitro.

@article{Herbert1988ActivityOP,
  title={Activity of pentosan polysulphate and derived compounds on vascular endothelial cell proliferation and migration induced by acidic and basic FGF in vitro.},
  author={J. J. Herbert and M Cottineau and F J Driot and J M Pereillo and Jean Pierre Maffrand},
  journal={Biochemical pharmacology},
  year={1988},
  volume={37 22},
  pages={4281-8}
}
Pentosan polysulphate (PPS, SP 54, HEMOCLAR), a highly sulphated semi-synthetic polysaccharide of MW 4700 Daltons is as efficient as heparin in potentiating the mitogenic activity of acidic FGF (aFGF) on human umbilical vein endothelial cells (HUVEC). When added to basic FGF (bFGF), no effect was observed on these cells. However, PPS had a strong inhibitory effect on the growth of bovine aortic endothelial cells (BAEC), as did heparin. PPS was fractionated according to molecular weight and the… CONTINUE READING

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