Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer’s disease

@article{Manuel2016ActivityOM,
  title={Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer’s disease},
  author={I Pena-Cruz Manuel and Laura Lombardero and Frank M. Laferla and Lydia Gim{\'e}nez-Llort and Rafael Rodr{\'i}guez-Puertas},
  journal={Neuroscience},
  year={2016},
  volume={329},
  pages={284-293}
}
Neurochemical alterations in Alzheimer's disease (AD) include cholinergic neuronal loss in the nucleus basalis of Meynert (nbM) and a decrease in densities of the M2 muscarinic receptor subtype in areas related to learning and memory. Neuromodulators present in the cholinergic pathways, such as neuropeptides and neurolipids, control these cognitive processes and have become targets of research in order to understand and treat the pathophysiological and clinical stages of the disease. This is… CONTINUE READING
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