Activity of murine raphe magnus cells predicts tachypnea and on-going nociceptive responsiveness.

@article{Hellman2007ActivityOM,
  title={Activity of murine raphe magnus cells predicts tachypnea and on-going nociceptive responsiveness.},
  author={Kevin M. Hellman and Thaddeus S. Brink and Peggy Mason},
  journal={Journal of neurophysiology},
  year={2007},
  volume={98 6},
  pages={3121-33}
}
In rats, opioids produce analgesia in large part by their effects on two cell populations in the medullary raphe magnus (RM). To extend our mechanistic understanding of opioid analgesia to the genetically tractable mouse, we characterized behavioral reactions and RM neural responses to opioid administration. d-Ala(2), N-Me-Phe(4)-Gly(5)ol-enkephalin, a mu-opioid receptor agonist, microinjected into the murine RM produced cardiorespiratory depression and reduced slow wave electroencephalographic… CONTINUE READING

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