Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and waking in the rat

@article{Miller1983ActivityOM,
  title={Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and waking in the rat},
  author={Joseph D. Miller and J. Farber and Pam Gatz and H. Roffwarg and D. German},
  journal={Brain Research},
  year={1983},
  volume={273},
  pages={133-141}
}
Single unit activity of dopamine and non-dopamine neurons in the substantia nigra and ventral tegmental area was recorded across stages of sleep and waking in the rat. These stages consisted of slow wave sleep (SWS), rapid eye movement (REM) sleep, awake-quiet (AQ) and awake-moving (AM). The dopamine neurons showed no change in mean firing rate across the stages of sleep or waking. During REM sleep, however, the dopamine cells fired with a more variable interspike interval than during SWS. In… Expand
Discharge Profiles of Ventral Tegmental Area GABA Neurons during Movement, Anesthesia, and the Sleep–Wake Cycle
TLDR
The findings indicate that the discharging of VTA GABA neurons correlates with psychomotor behavior and that these neurons may be an integral part of the extrathalamic cortical activating system. Expand
Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures
TLDR
The results show that sleep and sleep disturbances significantly affect neuronal activity in midbrain DA structures and it is proposed that these changes in neuronal activity underlie the well-known relationship between sleep alterations and several disorders involving dysfunction of the DA circuitry such as addiction and depression. Expand
Interplay of dopamine and GABA in substantia nigra for the regulation of rapid eye movement sleep in rats
TLDR
It is suggested that the SN-DA-ergic neurons act on theSN-GABA-ergic to regulate REMS, which advances the understanding of the neuro-anatomo-chemical connections and pharmaco-physiological regulation of REMS in health and diseases. Expand
Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep
TLDR
Challenging the traditional view that dopamine is the only aminergic group not involved in sleep physiology, this study provides an alternative perspective that may be crucial for understanding the physiological function of PS and dream mentation. Expand
Neurobiology of waking and sleeping.
  • B. Jones
  • Biology, Medicine
  • Handbook of clinical neurology
  • 2011
TLDR
This chapter discusses the neurobiology of waking and sleeping, which is actively generated by neuronal systems distributed through the brainstem and forebrain with different projections, discharge patterns, neurotransmitters, and receptors. Expand
Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice
TLDR
It is found that activation of dopamine neurons in the ventral tegmental area (VTA), but not in the substantia nigra, strongly induced wakefulness, although both cell populations expressed the neuronal activity marker c-Fos after chemogenetic stimulation. Expand
Dopamine Control of Arousal
An important role for dopamine (DA) in the regulation of sleep–wakefulness and cortical arousal has been established, challenging the traditional view that DA is the only central aminergic group notExpand
Dopamine and Sleep
TLDR
The dopamine (DA)-ergic neurons are primarily localized in the substantia nigra and ventral tegmental area of the brainstem and may have an indirect modulatory role, which however needs confirmation. Expand
Functional Interactions Between MCHergic and Dopaminergic Neurons: Role in the Control of Wakefulness and Sleep
TLDR
Indirect evidence strongly suggests that functional interactions between the MCHergic and DAergic systems play an important role in the control of behavioral states and in the regulation of different aspects of REM sleep. Expand
Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep–wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats
TLDR
The results demonstrate that contrary to the findings of earlier electrophysiologic studies carried out on ventral tegmental area dopaminergic neurons, changes in the release of dopamine in projection areas occur across the sleep–wake cycle. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Single unit activity of dopaminergic neurons in freely moving cuts.
TLDR
This study represents the first systematic report providing evidence for recording the activity of dopaminergic neurons in freely moving cats, and when these cells were studied across the sleep-waking cycle they displayed little variation in firing rates between waking, slow wave sleep and REM sleep. Expand
Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra
TLDR
D dopamine (DA)-containing and other output neurons of the substantia nigra (SN) wer identified by antidromic stimulation from postulated target nuclei, the caudate-putamen, the thalamus, the cortex and the pontine reticular formation to constitute a second, non-DA, fast-conducting nigrostriatal pathway. Expand
Spontaneous activity of cat hippocampal neurons in sleep and wakefulness.
Abstract Spontaneous activity of the hippocampal pyramidal cells in chronically prepared cats was recorded for extended periods, thus allowing analysis of temporal patterns of neuronal discharges inExpand
Electrophysiological studies of neurons in the ventral tegmental area of tsai
TLDR
Results provide further evidence of a GABAergic input to dopaminergic and non-dopaminergic neurons projecting to the limbic forebrain structures. Expand
Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
  • G. Aston-Jones, F. Bloom
  • Psychology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1981
TLDR
The NE-LC system may globally bias the responsiveness of target neurons and thereby influence overall behavioral orientation, generally consistent with previous proposals that the NE- LC system is involved in regulating cortical and behavioral arousal. Expand
Electrophysiological examination of the ventral tegmental (A10) area in the rat
TLDR
The purpose of the present study was to examine the responses of A10 DA neurons in the rat following electrical stimulation of the nucleus accumbens and olfactory tubercle. Expand
Sensory stimuli alter discharge rate of dopamine (DA) neurons: evidence for two functional types of DA cells in the substantia nigra
TLDR
It is demonstrated that dopaminergic neurons located in the substantia nigra of the rat respond to sensory stimuli, and that two functionally distinct DA cell types exist within this region. Expand
Effect of sensory stimuli on the activity of dopaminergic neurons: involvement of non-dopaminergic nigral neurons and striato-nigral pathways.
TLDR
It is suggested that sensory stimuli may induce an initial inhibition of dopaminergic neurons, at least in part, through excitation of an inhibitory non-dopaminergic zona reticulata neuron. Expand
Mesencephalic dopaminergic unit activity in the behaviorally conditioned rat.
TLDR
It is indicated that some DA cells change their firing pattern following behaviorally relevant stimuli, and that the incidence of spontaneously active DA neurons is low in the awake rat. Expand
Electrophysiological evidence for non-dopaminergic mesocortical and mesolimbic neurons in the rat
The neurons located in the ventromedial tegmentum (VMT) and projecting either to the frontal cortex, to the septum or to the nucleus accumbens were identified by the antidromic activation method inExpand
...
1
2
3
...