Activity of intraperitoneal heparin during peritoneal dialysis.

  title={Activity of intraperitoneal heparin during peritoneal dialysis.},
  author={K I Furman and Edward Gomperts and J M Hockley},
  journal={Clinical nephrology},
  volume={9 1},
A pharmacokinetic study of intraperitoneal heparin was undertaken in eleven chronic renal failure patients as a guide for its therapeutic use in peritoneal dialysis. The intraperitoneal heparin was assayed as the activated-partial-thromboplastin time (A-PTT) of peritoneal aspirate or outflow dialyzate added to control plasma. This was noted to decay relatively slowly, the mean t 1/2 of heparin in the peritoneal cavity being 10.8 +/- 0.93 hr. The heparin cofactor antithrombin III determined by… CONTINUE READING

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