Activity of human pregnancy insulin-like growth factor binding protein-3: determination by reconstituting recombinant complexes.

@article{Yan2009ActivityOH,
  title={Activity of human pregnancy insulin-like growth factor binding protein-3: determination by reconstituting recombinant complexes.},
  author={Xiaolang Yan and Louis D Payet and Robert C. Baxter and Sue M. Firth},
  journal={Endocrinology},
  year={2009},
  volume={150 11},
  pages={4968-76}
}
During pregnancy, IGF binding protein-3 (IGFBP-3) is completely proteolyzed to fragments with low affinities for IGFs but appears to transport IGFs normally in high-molecular-mass complexes. We previously reported that synthetic isolated amino- and carboxyl-terminal domains of IGFBP-3 cooperate to bind IGFs, and we investigated whether this is the mechanism whereby proteolyzed IGFBP-3 fragments bind IGFs normally in pregnancy serum. Two fragments of IGFBP-3 have been isolated from pregnancy… CONTINUE READING

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