Activity of human contact allergens in the murine local lymph node assay.

  title={Activity of human contact allergens in the murine local lymph node assay.},
  author={Cindy A. Ryan and G. Frank Gerberick and Lynn W Cruse and David A Basketter and Laura Lea and L Blaikie and Rebecca Jane Dearman and E Vicky Warbrick and I A N Kimber},
  journal={Contact dermatitis},
  volume={43 2},
The murine local lymph node assay (LLNA) is a predictive test for the identification of chemicals that have the potential to cause skin sensitization. Since its original development, the assay has been the subject of national and international evaluation studies and extensive comparisons with guinea pig tests and human data. On the basis of these investigations, the LLNA has recently been endorsed by ICCVAM (Interagency Coordinating Committee on the Validation of Alternative Methods) as a stand… CONTINUE READING


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