Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis.

@article{Hennings1992ActivityOD,
  title={Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis.},
  author={Henry Hennings and David T Lowry and Victor A. Robinson and David M. L. Morgan and Hirota Fujiki and Stuart H. Yuspa},
  journal={Carcinogenesis},
  year={1992},
  volume={13 11},
  pages={2145-51}
}
The suppression of focal growth of initiated mouse keratinocytes by co-culture with normal keratinocytes can be overcome by treatment of co-cultures with the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). This keratinocyte co-culture model was developed as an analog of initiated mouse epidermis to facilitate the study of tumor promotion in cell culture. A number of promoters of TPA-type [those with protein kinase C (PKC) as receptor] were compared to non-TPA-type… CONTINUE READING

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