Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

@inproceedings{Rahman2017ActivityOD,
  title={Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes},
  author={Mumtahena Rahman and Shelley M. MacNeil and David F Jenkins and Gajendra Shrestha and Sydney R. Wyatt and Jasmine A. McQuerry and Stephen R. Piccolo and Laura Heiser and Joe W. Gray and William E. Johnson and Andrea H Bild},
  booktitle={Genome Medicine},
  year={2017}
}
The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in patient tumors. Here, pathway-specific genomic signatures were used to… CONTINUE READING