Activity of distamycin A on the induction of adaptive enzymes in Escherichia coli.

@article{Sanfilippo1966ActivityOD,
  title={Activity of distamycin A on the induction of adaptive enzymes in Escherichia coli.},
  author={Aurora Sanfilippo and E. Morvillo and Mario Ghione},
  journal={Journal of general microbiology},
  year={1966},
  volume={43 3},
  pages={
          369-74
        }
}
SUMMARY: We have studied the effect of distamycin A on the synthesis of inducible enzymes in Escherichia coli strain K12. Distamycin A did not inhibit the growth of E. coli K12 when the micro-organism already contained constitutive or inducible enzymes for the metabolism of sugars. The growth of E. coli was prevented when distamycin A was present during the enzymic induction. Distamycin A inhibited the formation of inducible β-galactosidase; the activity of the antibiotic was directly related… 
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Results suggest that netropsin may be affecting the transcription of only select sporulation genes that are particularly rich in adenylate-thymidylate base pairs.
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Distamycin A inhibits deoxyribonucleic acid (DNA)-mediated transformation and transfection in Bacillus subtilis at doses with little or no antibacterial effect, demonstrating that the drug acts by inhibiting DNA uptake.
Selective inhibition of sporulation of Bacillus subtilis by netropsin.
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Wirkung von Distamycin A und Netropsin auf normale und zellwandlose Zellen von Escherichia coli W1655F
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The authors' experiments with the normal rod form and the stable protoplast type L- form of E. coli W1655F+ have shown that distamycin A inhibits gramnegative bacteria to the same extent as netropsin, when wall-less L-form-ells were used.
Studies on the interaction of distamycin A and its derivatives with DNA.
ACTIVITY OF DISTAMYCIN A ON THE TRANSFER OF DRUG RESISTANCE IN GRAM‐NEGATIVE CLINICAL ISOLATES
  • A. Sanfilippo
  • Biology
    Annals of the New York Academy of Sciences
  • 1971
TLDR
Findings suggest the hypothesis of a possible interference of distamycin A with the resistance transfer processes in some strains of gramnegative clinical isolates.
...
...

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