Activity of creatine kinase in a contracting mammalian muscle of uniform fiber type.

@article{McFarland1994ActivityOC,
  title={Activity of creatine kinase in a contracting mammalian muscle of uniform fiber type.},
  author={Eric W. McFarland and Martin J. Kushmerick and Timothy S. Moerland},
  journal={Biophysical journal},
  year={1994},
  volume={67 5},
  pages={1912-24}
}
We investigated whether the creatine kinase-catalyzed phosphate exchange between PCr and gamma ATP in vivo equilibrated with cellular substrates and products as predicted by in vitro kinetic properties of the enzyme, or was a function of ATPase activity as predicted by obligatory "creatine phosphate shuttle" concepts. A transient NMR spin-transfer method was developed, tested, and applied to resting and stimulated ex vivo muscle, the soleus, which is a cellularly homogeneous slow-twitch… CONTINUE READING

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