Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice.

@article{Keiser2010ActivityOA,
  title={Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice.},
  author={Jennifer Keiser and M. Garc{\'i}a Vargas and Michael J. Doenhoff},
  journal={The American journal of tropical medicine and hygiene},
  year={2010},
  volume={82 1},
  pages={112-4}
}
Immune effector mechanisms can enhance the activity of antischistosomal drugs. We examined the in vivo effect of single oral doses of the antimalarials artemether (400 mg/kg) and mefloquine (200 mg/kg), recently described to have promising antischistosomal properties, against juvenile and adult Schistosoma mansoni in T cell-deficient and in comparably infected age- and sex-matched immunologically intact control mice. Artemether and mefloquine are equally effective in athymic and immunocompetent… CONTINUE READING

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