Activity of anti-epidermal growth factor receptor monoclonal antibody C225 against glioblastoma multiforme.

@article{Eller2002ActivityOA,
  title={Activity of anti-epidermal growth factor receptor monoclonal antibody C225 against glioblastoma multiforme.},
  author={Jorge L. Eller and Sharon L. Longo and Daniel J. Hicklin and Gregory W. Canute},
  journal={Neurosurgery},
  year={2002},
  volume={51 4},
  pages={1005-13; discussion 1013-4}
}
OBJECTIVE Overexpression of epidermal growth factor receptor (EGFR) in glioblastoma multiforme (GBM) secondary to EGFR gene amplification is associated with a more aggressive tumor phenotype and a worse clinical outcome. The purpose of this study was to analyze whether blocking this receptor with the anti-EGFR chimeric monoclonal antibody C225 would decrease proliferation and increase apoptosis in GBM cells. METHODS EGFR expression and amplification were analyzed for seven human GBM cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Advances in Biology and Treatment of Glioblastoma

Somasundaram
Current Cancer Research • 2017

Similar Papers

Loading similar papers…