Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism.

@article{Racchi1999ActivityOA,
  title={Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism.},
  author={Marco Racchi and D C Solano and Marina Sironi and Stefano Govoni},
  journal={Journal of neurochemistry},
  year={1999},
  volume={72 6},
  pages={2464-70}
}
The metabolic fate of the amyloid precursor protein (APP) is one of the key factors in the pathogenesis of Alzheimer's disease (AD). A complex cellular mechanism regulates the rate at which the precursor is cleaved by alpha-secretase and released as soluble protein in the extracellular space. We show here that alpha-secretase constitutes the common final effector of several independent means of stimulation of soluble APP (sAPP) release. The release of sAPP by alpha-secretase resembles that of… CONTINUE READING