Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins.

@article{Gautschi2001ActivityOA,
  title={Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins.},
  author={Oliver Gautschi and Stefan Tschopp and Robert A. Olie and Si{\^a}n H. Leech and Ana Paula Sim{\~o}es-W{\"u}st and Andreas Ziegler and Bernd Baumann and Bernhard Odermatt and Janet A. Hall and Rolf Arno Stahel and Uwe Zangemeister-Wittke},
  journal={Journal of the National Cancer Institute},
  year={2001},
  volume={93 6},
  pages={
          463-71
        }
}
BACKGROUND Increased expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL is involved in the development and progression of many tumors. We recently reported that the bcl-2/bcl-xL-bispecific antisense oligonucleotide 4625 induces apoptosis in lung carcinoma cells. To further assess the therapeutic potential of oligonucleotide 4625, we investigated its effect on a series of human tumor cell lines of diverse histologic origins in vitro and in vivo. METHODS Oligonucleotide 4625-mediated… CONTINUE READING

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