Activity of a new oxadiazole compound, against experimental infections with Entamoeba histolytica and Giardia lamblia in animal models.

  title={Activity of a new oxadiazole compound, against experimental infections with Entamoeba histolytica and Giardia lamblia in animal models.},
  author={K. Bhopale and K. Pradhan and P. G. Phaltankar and K. Masani and C. Kaul},
  journal={Annals of tropical medicine and parasitology},
  volume={87 2},
BTI 2286E(+/-)-E-3-(4-methylsulphinylstyryl)-1,2,4-oxadiazole has demonstrated potent amoebicidal activity in a single-dose treatment against Entamoeba histolytica infection in the livers of golden hamsters and the caeca of mice, hamsters and rats. It has intra luminal activity against Entamoeba criceti, a natural infection in golden hamster, and anti-giardial activity against Giardia lamblia infection in suckling mice. BTI 2286E is more potent than metronidazole in extra intestinal, intra… Expand
Heterocyclic Lead Compounds Against Amebiasis
Amebiasis is a widespread parasitic disease caused by Entamoeba histolytica. This protozoan organism is the third leading parasitic cause of death in the developing world. Nitroimidazole-based drugsExpand
A comparative study of experimental caecal amoebiasis and the evaluation of amoebicides.
The mouse model appears to be the most useful for primary screening of anti-amoebic compounds, and a new oxadiazole compound, BTI 2405E, was found to have tissue and luminal amoebicidal activity. Expand
The old and new therapeutic approaches to the treatment of giardiasis: Where are we?
This study is a review of drugs used in in vitro and in vivo tests, and also drugs tested in clinical trials (nonrandomized and randomized). Expand
Mannich base derivatives of 1,3,4-oxadiazole: synthesis and screening against Entamoeba histolytica
Mannich base derivatives of 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-(3H)-thione with substituted piperazine were synthesized and characterized. In vitro antiamoebic activity was performed against HM1:Expand
Tesis (Doctorado en Ciencias en Investigacion en Medicina), Instituto Politecnico Nacional, SEPI, ESM, 2007, 1 archivo PDF, (116 paginas).
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    Comparative studies on the amoebicidal activity of known 5-nitroimidazole derivatives and CG 10213-Go in golden hamsters, Mesocricetus auratus, infected in the liver or caecum or both with trophozoites of Entamoeba histolytica.
    CG 10213-Go, a 5-nitroimidazole derivative synthesized at the CIBA-Geigy Research Centre, Bombay, proved superior to such currently used 5-nitroimidazole derivatives as metronidazole, ornidazole,Expand
    Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis.
    A novel tetrahydroquinolinyl ester administered orally in multiple doses for 3 days had an ED50 of 0.25 mg/kg/day for eradicating Entamoeba criceti in hamsters in several tests, and was significantly more active by direct comparison than 3 commercially available amoebicides and at least as active as 2 other esters of the parent compound. Expand
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    A series of 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinols and certain O-acyl derivatives thereof have been prepared and shown to be potent antiamebic agents in the Entamoeba criceti infectedExpand