Activity of Wnt-1 as a transmembrane protein.

  title={Activity of Wnt-1 as a transmembrane protein.},
  author={N. Parkin and Jan Kitajewski and H. E. Varmus},
  journal={Genes & development},
  volume={7 11},
The product of the Wnt-1 proto-oncogene is a cysteine-rich glycoprotein that plays a crucial role in the development of the vertebrate central nervous system. Wnt-1 protein is secreted but remains associated with the cell surface and extracellular matrix. The function of Wnt-1 in several different biological settings can be carried out by cells that receive the Wnt signal from adjacent cells. Ectopic expression of Wnt-1 in certain mammary gland cell lines, such as C57MG, causes morphological… CONTINUE READING


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